Podczas ataku padaczki dochodzi do nadmiernego zwiększenie aktywności neuronów. Zmęczenie, alkohol, kawa, psychodeliki, aktywność intelektualna to zjawiska sprzyjające demineralizacji. Demineralizacja sprzyja zaburzeniom przesyłu sygnałów elektrycznych w mózgu.
Zapobiegłem atakowi wypijając szklankę wody z solą. Odczucie "iskrzenia" w środku głowy minęło w ciągu pół minuty. Uświadomiłem je sobie wystarczająco wcześnie.
Scientists think they've found out what could be at the root of autism and, no, it's not vaccines. According to a new study, it could be caused by having too many brain connections called synapses.
"An increased number of synapses creates miscommunication
among neurons in the developing brain that correlates with impairments
in learning, although we don’t know how,” senior author Azad Bonni, head
of the Department of Neuroscience at Washington University School of
Medicine in St. Louis, explained in a statement.
Autism spectrum disorder (ASD)
is a common neurodevelopmental condition affecting one in 68 people in
the United States. It's generally understood that there is a genetic
aspect to ASD (it often runs in families), though environmental triggers may also play a role.
Several genes have
been linked to people with autism. Six of these are called ubiquitin
ligases and they're responsible for attaching molecular tags called
ubiquitins to proteins. Think of these genes as managers, telling their
employees (the rest of the cell) how to handle the tagged proteins.
Should they be discarded? Should they be taken to another part of the
cell?
Some experts believe that individuals with autism have a
gene mutation preventing one of their ubiquitin ligases from working
correctly. To find out how and why this might be, the scientists at
Washington University removed RNF8 (a ubiquitin gene) in neurons in the
cerebellum (an area of the brain affected by autism) of young mice. The
mice missing the gene developed an excess of synapses, which in turn
affected their ability to learn.
Those mice had 50 percent more synapses than their peers,
who had their RNF8 gene intact. The scientists then measured the
electrical signal in the neurons and found that it was twice as strong
compared to those with a normal functioning cell.
ASD affects language, attention, and movement; skills the
cerebellum plays an essential role in. To see if the test mice had lower
motor skills (a common symptom in people with autism), the
researchers trained the mice to associate a puff of air to the eye with a
blinking light. One week later, the control group avoided
the irritation caused by the puff of air by closing their eyes 75
percent of the time. The test group only did so one-third of the time.
The scientists point out that a mouse that doesn’t shut its
eyes when trained doesn’t quite equate to a human with autism (after
all, the wiring of autistic brains is highly individualized),
and more work is needed to verify the hypothesis. But it does reveal an
interesting association between synapses and behavior that could one
day lead to treatments.
za:
http://www.iflscience.com/health-and-medicine/scientists-may-have-found-the-root-cause-of-autism/
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